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Trastuzumab may induce LV remodeling despite exercise; leaves open long-term consequences and optimal prevention strategies.
Initiation of adjuvant trastuzumab therapy is associated with LV cavity dilation and reduced ejection fraction despite aerobic exercise training. The long-term consequences of trastuzumab-induced LV remodeling and the means to prevent LV dysfunction require further study.
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Haykowsky et al. (2009) studied this question.
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