N⁶ -methyladenosine (m⁶ A) RNA modification, first discovered in 1974, is the most prevalent, abundant and penetrating messenger RNA (mRNA) modification in eukaryotes. This governs the fate of modified transcripts, regulates RNA metabolism and biological processes, and participates in pathogenesis of numerous human diseases, especially in cancer through the reciprocal regulation of m⁶ A methyltransferases ("writers") and demethylases ("erasers") and the binding proteins decoding m⁶ A methylation ("readers"). Accumulating evidence indicates a complicated regulation network of m⁶ A modification involving multiple m⁶ A-associated regulatory proteins whose biological functions have been further analysed. This review aimed to summarize the current knowledge on the potential significance and molecular mechanisms of m⁶ A RNA modification in the initiation and progression of cancer.
No takes yet. Share an insight, caveat, or question.
Huo et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: