December 18, 2014Journal of VirologyOpen Access

The Stress Granule Protein G3BP1 Recruits Protein Kinase R To Promote Multiple Innate Immune Antiviral Responses

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Population

virus-infected cells

Design

Preclinical

Authors

LRLucas C. ReinekeCodexis (United States)RLRichard E. LloydUniversity of Minnesota

Discussion

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Implication

Animal data identify G3BP1-PKR axis for antiviral defense; leaves open therapeutic translation to human viral infections.

Structured PICO

Population

virus-infected cells

Outcome

activation of PKR and other innate immune pathways

The study refines the paradigm of stress granules by showing they are not inert artifacts, but actively promote innate immune antiviral responses via G3BP1 and PKR.

Cite This Study

Reineke et al. (2014) studied this question.

synapsesocial.com/papers/69deace7499d77a496b0c7d1 https://doi.org/10.1128/jvi.02791-14

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The Stress Granule Protein G3BP1 Recruits Protein Kinase R To Promote Multiple Innate Immune Antiviral Responses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Stress Granule Protein G3BP1 Recruits Protein Kinase R To Promote Multiple Innate Immune Antiviral Responses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider