Does pretreatment with mitochondria-targeted peptides SS-31 and SS-20 reduce myocardial lipid peroxidation and infarct size in a rat model of ischemia-reperfusion injury?
Mitochondria-targeted peptides SS-31 and SS-20 demonstrate cardioprotective properties by reducing infarct size and oxidative stress in a preclinical model of ischemia-reperfusion injury.
This study shows that pretreatment with both SS-31 and SS-20 significantly reduced myocardial lipid peroxidation and infarct size in ischemia-reperfusion injury, and suggests that the cardioprotective properties of 2',6'-dimethyl-tyrosine-D-Arg-Phe-Lys-NH2 was primarily mediated by its antioxidant properties. As SS-20 does not scavenge reactive oxygen species, it most likely reduces reactive oxygen species production during ischemia-reperfusion.
Cho et al. (Wed,) studied this question.