Why the study?
Does salicylaldehyde isonicotinoyl hydrazone (SIH) protect adult cardiomyocytes against H2O2 injury compared to DFO or MIA?
Does salicylaldehyde isonicotinoyl hydrazone (SIH) protect adult cardiomyocytes against H2O2 injury compared to DFO or MIA?
The novel iron chelator SIH demonstrates rapid and potent protection against oxidative stress in adult cardiomyocytes, suggesting potential as a cardioprotective agent.
The data indicate that SIH provides a very powerful and very fast protection against the oxidative stress exerted by H(2)O(2) presumably via the iron-mediated Fenton reaction producing hydroxyl radical (OH), whereas the protective effect of DFO is hindred by its very slow and rather limited intracellular entry, and the protection that MIA exerts via the inhibition of Na(+)/H(+) exchange against H(2)O(2) much less effective.
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M Horácková (2000) studied this question.
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