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March 18, 2020Circulation84 citationsOpen Access

Heart-Specific Immune Responses in an Animal Model of Autoimmune-Related Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation

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MBMariella BockstahlerAFAndrea FischerCGCarl Christoph Goetzke

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Abstract

By reversing heart-specific autoimmune responses, immunoproteasome inhibitors applied to a mouse model demonstrate their potential to aid in the management of autoimmune myocarditis in humans, possibly including patients with ICI-related heart-specific autoimmunity.

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Bockstahler et al. (2020) studied this question.

synapsesocial.com/papers/69dec56d5e217d93a555876dhttps://doi.org/10.1161/circulationaha.119.043171
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