Abdominal perivascular adipose tissue lacks the anti-contractile function and eNOS-derived NO production seen in thoracic PVAT, which may contribute to regional differences in susceptibility to vascular injury such as atherosclerosis.
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Abdominal aortic PVAT dysfunction may heighten injury risk; hypothesis-generating for regional eNOS-targeted therapies.
Victório et al. (2016) studied this question.
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