Antimicrobial, antioxidant and anticancer activities of Laurencia catarinensis , Laurencia majuscula and Padina pavonica extracts

The antimicrobial, antioxidant, and anticancer activities of ethanolic extract of Laurencia catarinensis, L. majuscula and Padina pavonica were determined. The highest antibacterial activity; 23.40 ± 0.58 mm (00.98 µg/ml) and 22.60 ± 2.10 mm (03.90 µg/ml) were obtained against Klebsiella pneumonia by Laurencia catarinensis and Padina pavonica, respectively. However, Padina pavonica showed excellent antibacterial activity against Bacillus subtilis (21.7 ± 1.5 mm; 1.95 µg/ml), Staphylococcus aureus (21.7 ± 0.58 mm; 1.95 µg/ml), Streptococcus pyogenes (20.7 ± 1.2 mm; 1.95 µg/ml) and Acinetobacter baumannii (20.1 ± 1.2 mm; 3.9 µg/ml). Moreover, the highest antifungal activity; 24.7 ± 2.0 mm (0.98 µg/ml), 23.7 ± 1.5 mm (0.98 µg/ml), 23.6 ± 1.5 mm (0.98 µg/ml) was obtained by Padina pavonica against Candida tropicalis, C. albicans and Aspergillus fumigatus, respectively. The algal extracts showed DPPH radical scavenging activity in a concentration-dependent manner with maximum scavenging activity (77.6%, IC₅₀ = 5.59 µg/ml and 77.07%, IC₅₀ = 14.3 µg/ml) was provided by Padina pavonica and Laurenica majuscula, respectively. The in vitro antitumor activity revealed that the IC₅₀ values of Padina pavonica were 58.9, 115.0, 54.5, 59.0, 101.0, 101.0, and 97.6 µg/ml; Laurencia catarinensis were 55.2, 96.8, 104.0, 78.7, 117.0, 217.0, 169.0 µg/ml; and Laurencia. majuscula were 115.0, 221.0, 225.0, 200.0, 338.0, 242.0, and 189.0 µg/ml; respectively against A-549 (Lung carcinoma), Caco-2 (Intestinal carcinoma), HCT-116 (Colon carcinoma), Hela (Cervical carcinoma), HEp-2 (Larynx carcinoma), HepG-2 (Hepatocellular carcinoma), and MCF-7 (Breast carcinoma) cell lines.