Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate

George A. Díaz; Lauren Krivitzky; Masoud Mokhtarani; William J. Rhead; James Bartley; Annette Feigenbaum; Nicola Longo; William Berquist; Susan A. Berry; Renata C. Gallagher; Uta Lichter‐Konecki; Dennis Bartholomew; Cary O. Harding; Stephen Cederbaum; Shawn E. McCandless; Wendy E. Smith; Jerry Vockley; Stephen A. Bart; Mark Korson; David Kronn; Roberto Zori; Lawrence Merritt; Sandesh C. Sreenath Nagamani; Joseph Mauney; Cynthia LeMons; Klara Dickinson; Tristen Moors; Dion F. Coakley; Bruce F. Scharschmidt; Brendan Lee

doi:10.1002/hep.26058

Abstract

Glycerol phenylbutyrate exhibits favorable pharmacokinetics and ammonia control relative to NaPBA in UCD patients, and long-term glycerol phenylbutyrate treatment in pediatric UCD patients was associated with improved executive function (ClinicalTrials.gov NCT00551200, NCT00947544, NCT00992459, NCT00947297). (HEPATOLOGY 2012).

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Díaz et al. (2012) studied this question.

synapsesocial.com/papers/69deccce488ed2d92be93f6f https://doi.org/10.1002/hep.26058

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Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate

Abstract

Discussion

Cite This Study

Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate

Abstract

Discussion

Cite This Study

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