January 2, 1990European Heart Journal

Abnormal intracellular calcium handling in acute and chronic heart failure: role in systolic and diastolic dysfunction

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Population

Animal and human models of acute and chronic heart failure

Design

Review

Authors

CPCynthia L. PerreaultBeth Israel Deaconess Medical Center AMArthur J. MeuseBeth Israel Deaconess Medical Center LBL A BentivegnaBeth Israel Deaconess Medical Center

Discussion

Member takes

Implication

Should not alter heart failure management; leaves open Ca2+ handling as a research target for new therapies.

Structured PICO

Population

Animal and human models of acute and chronic heart failure (including ferrets, Syrian hamsters, rats, and humans with end-stage dilated and hypertrophic cardiomyopathy)

Outcome

Mechanisms of systolic and diastolic dysfunctionsurrogate

This review highlights that abnormal intracellular calcium handling is a central mechanism underlying both systolic and diastolic dysfunction across various models of acute and chronic heart failure.

Cite This Study

Perreault et al. (1990) studied this question.

synapsesocial.com/papers/69decfb740ea0656795599a8 https://doi.org/10.1093/eurheartj/11.suppl_c.8

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