The present study was carried out to synthesize a series of some Novel N-carbamoyl pyrazoline derivatives, their docking studies and study their biological activities, in vitro antiinflammatory, antioxidant and antidiabetic activities. Title compounds were synthesized by the reaction of pyrazole based chalcones and semicarbazide in the presence of NaOH. The pyrazole chalcones in turn were synthesized by condensation of pyrazole aldehyde with various substituted acetophenones. Synthesis of pyrazole aldehyde was carried out by vilsmeir Hack formylation of phenyl hydrazones. All synthesized N-carbamoyl pyrazolines were studied for their in vitro anti-inflammatory, antioxidant and antidiabetic activities. A docking study was carried out for antiinflammatory and antidiabetic activity. Some of the synthesized compounds show excellent anti-inflammatory activity in comparison to standard Diclofenac sodium whereas some N-carbamoyl pyrazolines show potent anti-inflammatory activity. On the other hand, the antioxidant study was carried out by studying % inhibition for 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical, Nitic Oxide free radical (NO . ) and Superoxide radical (SOR) in comparison to standard ascorbic acid. Synthesized pyrazolines showed excellent to good antioxidant activity. The antidiabetic activity was carried out by assay of -amylase inhibition using acarbose as standard. All synthesized N-carboamyl pyrazolines showed potent to moderate antidiabetic activity.
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Peerzade et al. (2020) studied this question.
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