Persons with subthreshold depression and anxiety have continuously elevated functional impairment compared to controls, suggesting a need for targeted preventive interventions.
May warrant monitoring for persistent impairment in subthreshold cases; leaves open whether preventive interventions reduce long-term disability.
Functional impairment in subthreshold respondents improved over time, but remained elevated compared to that of controls. Given continuously elevated levels of impairment, preventive interventions should be focused on persons with subthreshold symptoms; in particular those with prior anxiety disorder, high neuroticism, low conscientiousness, somatic conditions, or childhood trauma.
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Karsten et al. (2012) studied this question.
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