Kinetic modeling of nicotine in mainstream cigarette smoking

The suggested mechanistic model for the formation of pyridine from the thermal degradation of nicotine in tobacco has been found to be agreement with the kinetic model proposed in this investigation. Consequently, the concentration of radical intermediates of tobacco smoke such as pyridinyl radical can be determined indirectly from a set of integrated rate laws. This study has also shown that different cigarettes can yield varying amounts of nicotine and pyridine depending on the type of cigarette primarily because of potential different growing conditions and additives introduced during tobacco processing. The activation energy of nicotine articulated in this work is consistent with that reported in literature.Graphical abstractThe anatomy of tobacco cigarette and the major chemistry involved during combustion (pyrolysis, GC-MS analysis, and kinetic modeling).