Findings demonstrate PCSK9's link to lipoprotein(a) levels, suggesting its role in cardiovascular risk assessment.
Our results show, for the first time, that plasma PCSK9 is found in association with Lp(a) particles in humans with high Lp(a) levels and in mice carrying human Lp(a). Lp(a)-bound PCSK9 may be pursued as a biomarker for cardiovascular risk.
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Tavori et al. (2016) studied this question.
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