Why the study?
Does peripheral administration of trandolapril versus lisinopril inhibit brain ACE in Wistar rats?
Does peripheral administration of trandolapril versus lisinopril inhibit brain ACE in Wistar rats?
Peripheral administration of hydrophilic ACE inhibitors can effectively inhibit brain ACE inside the blood-brain barrier in a rat model.
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Rat data on hydrophilic ACE inhibitor brain penetration remain hypothesis-generating; human studies needed before clinical relevance can be assessed.
These results suggest that peripheral administration of even hydrophilic ACE inhibitors can result in marked inhibition of brain ACE inside the BBB but that different brain structures show variable inhibition.
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Tan et al. (2005) studied this question.
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