Why the study?
Does the long-term administration of proton pump inhibitors increase the risk of adverse cardiovascular outcomes?
Comparison
Long-term PPI use vs non-use
Design
Umbrella review
Authors
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Caution advised with long-term PPI use; leaves open definitive causality for MACE.
Does the long-term administration of proton pump inhibitors increase the risk of adverse cardiovascular outcomes?
An umbrella review suggests a potential causal relationship between long-term PPI use and increased risk of MACE, highlighting the need to carefully weigh risks and benefits.
Teperikidis et al. (2023) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: