Why the study?
What are the histopathological changes and infected cell types during human norovirus infection in immunocompromised transplant patients?
Population
Immunocompromised transplant patients with and without human norovirus infection.
Comparison
Intestinal biopsy analysis for histopathological… vs Biopsies from non-infected transplant patients.
Design
Cross-sectional
Authors
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Enterocytes emerge as key HuNoV replication sites in immunocompromised transplant recipients; leaves open therapeutic targeting and generalizability beyond this cohort.
What are the histopathological changes and infected cell types during human norovirus infection in immunocompromised transplant patients?
Human enterocytes are identified as a physiologically relevant cell type for human norovirus replication in immunocompromised transplant patients.
Karandikar et al. (2016) studied this question.
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