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Synapse
April 15, 20260 citations

Fraxin as a promising molecule in the pharmacological treatment of acute mesenteric ischemia: an experimental study.

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IAIsmail AydinGiresun UniversityFUFurkan Ali UygurGiresun UniversityÖEÖmer EmecenGiresun University

Key Points

  • This research aims to evaluate the therapeutic effects of fraxin in treating acute mesenteric ischemia-reperfusion injuries.
  • Administered fraxin in an acute mesenteric artery ischemia-reperfusion injury model.
  • Assessed tissue preservation and antioxidant parameters post-treatment.
  • Measured levels of oxidative stress and inflammation.
  • Fraxin administration significantly preserved affected tissues.
  • Improved antioxidant parameters were observed following fraxin treatment.
  • Oxidative stress and inflammation levels were notably reduced.

Abstract

Fraxin administration preserved tissues and improved antioxidant parameters by reducing oxidative stress and inflammation in the acute mesenteric artery ischemia-reperfusion injury (AMAIRI) model. Based on these findings, fraxin may be considered a potential therapeutic option for mesenteric ischemia-reperfusion-related injuries.

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Cite This Study

Aydin et al. (2026) studied this question.

synapsesocial.com/papers/69df2ae6e4eeef8a2a6afdc0https://doi.org/10.14744/tjtes.2025.21860
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activation of autophagy through Sirt1/AMPK/mTOR mediates the protective effects of fraxin against insulin resistance and steatosis in rats2026
  2. 2Fraxin Attenuates Rheumatoid Arthritis by Regulating Macrophage Polarization and Inhibiting Fibroblast-like Synoviocyte Proliferation2026
  3. 3Fucoxanthin Attenuates Myocardial Ischemia/Reperfusion‐Induced Injury via AMPK / GSK ‐3β/Nrf2 Axis2024 · 10 citations
  4. 4Fraxetin pretreatment alleviates cisplatin‐induced kidney injury by antagonizing autophagy and apoptosis via mTORC1 activation2024 · 6 citations
  5. 5A Novel Analog of the Natural Product Fraxinellone Protects against Endogenous and Exogenous Neurotoxicants2024 · 3 citations