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April 15, 2026Journal of Materials Science Materials in MedicineOpen Access

Enhancing the osteogenic potential of 3D-printed polycaprolactone/hydroxyapatite composite scaffolds via in-situ ZIF-8 surface modification

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Authors

SMSaba MoslemiGDGhasem DiniFEFatemeh Ejeian

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Overview

Enhanced bioactivity and osteogenic performance of modified scaffolds in bone regeneration, suggesting potential clinical applications.

Key Points

  • This study aims to improve the osteogenic potential of 3D-printed PCL/HA composite scaffolds using ZIF-8 surface modification.
  • Developed PCL/HA scaffolds through fused deposition modeling.
  • Synthesized HA nanoparticles with high crystallinity and specific surface area.
  • Compared ZIF-8 modified scaffolds to unmodified controls in in vitro experiments.
  • ZIF-8 modification significantly improved cell adhesion and proliferation.
  • 2.1-fold increase in alkaline phosphatase activity on modified scaffolds.
  • 2.5-fold increase in BMP2 gene expression after 21 days of cell induction.

Cite This Study

Moslemi et al. (2026) studied this question.

synapsesocial.com/papers/69df2b04e4eeef8a2a6b0048https://doi.org/10.1007/s10856-026-07029-y
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Also Consider

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