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April 15, 2026International Journal of Molecular SciencesOpen Access

Single-Cell Immune Atlases to Map Small Extracellular Vesicle Cargo in Tuberculosis–Diabetes Comorbidity: A Narrative Review and Conceptual Roadmap

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Authors

RCRamona CioboatăSVSilviu Gabriel VlasceanuDMDenisa Maria Mitroi

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Overview

Narrative review explores immune dysfunction and small extracellular vesicles in tuberculosis–diabetes comorbidity, suggesting new insights.

Key Points

  • The review aims to bridge the gap between small extracellular vesicle cargo and immune dysfunction in tuberculosis–diabetes comorbidity.
  • Narrative review of studies from 2010 to 2026 focused on tuberculosis and diabetes mellitus.
  • Utilization of single-cell and multimodal immune reference atlases such as scRNA-seq and CITE-seq.
  • Development of frameworks for linking EV cargo to immune cell states and anatomic compartments.
  • Highlighting challenges in interpreting EV studies due to heterogeneous mixtures and selective cargo packaging.
  • Conventional analyses often overlook clinically relevant immune dysfunction in TB-DM.
  • Single-cell atlases could help identify specific immune cell states linked to EV cargo patterns.
  • Proposed frameworks aim to improve identification of biomarkers for treatment response and immunopathology.

Cite This Study

Cioboată et al. (2026) studied this question.

synapsesocial.com/papers/69df2b2ce4eeef8a2a6b0210https://doi.org/10.3390/ijms27083437
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the Role of Extracellular Vesicles in the Pathogenesis of Tuberculosis2024 · 4 citations
  2. 2Integrated multi-omics profiling reveals immune-related biomarkers and regulatory networks for early prediction of tuberculosis in type 2 diabetes mellitus2026
  3. 3Recent Advances in Biomarkers for Diabetes Mellitus and Tuberculosis Comorbidity: A Comprehensive Review2025
  4. 4Single-cell RNA sequencing reveals immune cell dysfunction and rewired interaction networks in the peripheral blood of active tuberculosis patients2025
  5. 5Integrated serum lipidomics and selected immune profiling identify immunometabolic alterations associated with T2DM-TB comorbidity2026