Prophylactic Antibiotic Use and Clinical Outcomes in Patients With Child–Pugh A Cirrhosis and Acute Variceal Bleeding: A Retrospective Cohort Study | Synapse
April 15, 2026Open Access
Prophylactic Antibiotic Use and Clinical Outcomes in Patients With Child–Pugh A Cirrhosis and Acute Variceal Bleeding: A Retrospective Cohort Study
Key Points
To examine the effect of prophylactic antibiotic use on clinical outcomes in patients with Child-Pugh A cirrhosis experiencing acute variceal bleeding.
Retrospective cohort study design
Assessment of clinical outcomes including treatment failure and mortality
Evaluation of patients with Child-Pugh A cirrhosis and acute variceal bleeding
Prophylactic antibiotic use showed no association with 5-day treatment failure
No significant difference in 6-week mortality rates between antibiotic users and non-users
Abstract
The antibiotics' prophylactic use was not associated with 5-day treatment failure or 6-week mortality. Prophylactic use of antibiotics may not be routinely necessary in patients with Child A cirrhosis and AVB.