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April 15, 2026Annual Review of Cancer Biology

The Angiocrine Niche in Cancer Therapy Responses: The Role of Vascular Endothelial Cells in Immunomodulation

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Key result

Tumor vascular endothelial cells contribute to cancer therapy resistance by secreting immune-modulating angiocrine factors.

Why the study?

Understanding complex endothelial cell-immune interactions within the tumor microenvironment is crucial for developing strategies to target the angiocrine axis and improve patient outcomes.

Design

Review

Authors

ALAbby LockwoodMBMadeleine BenguiguiKHKairbaan Hodivala-Dilke

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Overview

May alter approaches to therapeutic resistance in solid tumors; extends endothelial-immune interface as actionable target for novel therapies.

Key Points

  • The aim is to explore how vascular endothelial cells in the tumor microenvironment affect immune responses and therapy resistance.
  • Review of existing literature on vascular endothelial cells and their immunological roles
  • Analysis of immunomodulatory endothelial cell states
  • Examination of therapeutic interventions impacting endothelial cell behavior
  • Vascular endothelial cells secrete angiocrine factors that influence cancer growth and immune functions.
  • Different phenotypes of immunomodulatory endothelial cells create either immune-responsive or treatment-resistant environments.
  • Therapeutic interventions can induce changes in endothelial cell signaling, contributing to resistance against treatment.

Structured PICO

P
Population
Vascular endothelial cells (ECs) within the tumor microenvironment (TME)

Understanding the complex interactions between vascular endothelial cells and the immune system in the tumor microenvironment is crucial for developing novel strategies to overcome cancer therapy resistance.

Cite This Study

Lockwood et al. (2026) conducted a review in Cancer. Vascular endothelial cells (angiocrine niche) was evaluated. Vascular endothelial cells within the tumor microenvironment act as immune gatekeepers, secreting angiocrine factors that modulate the immune landscape and contribute to cancer therapy resistance.

synapsesocial.com/papers/69df2bcae4eeef8a2a6b0c45https://doi.org/10.1146/annurev-cancerbio-071124-032538
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