From Statistical Mixtures to Structural Insights: Characterisation of Heterometallic [M ₄ L ₆ ] ⁸⁺ Coordination Cages using High Resolution Ion Mobility Mass Spectrometry

Fangxing Hong; Michael C. Pfrunder; David Marshall; Therese M. Fulloon; Stephen J. Blanksby; Berwyck L. J. Poad; Jack Kay Clegg; John C. McMurtrie; Kathleen Mullen

doi:10.1039/d6cc01216g

January 1, 2026Chemical Communications

From Statistical Mixtures to Structural Insights: Characterisation of Heterometallic [M ₄ L ₆ ] ⁸⁺ Coordination Cages using High Resolution Ion Mobility Mass Spectrometry

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Key Points

This research aims to characterize heterometallic coordination cages using advanced mass spectrometry techniques.
Utilized high-resolution ion mobility mass spectrometry to analyze coordination cages.
Focused on identifying structural differences between substrates.
Compared multiple metal-ligand arrangements for detailed analysis.
Successfully distinguished between various substrates based on their structural features.
Revealed intricate details of the three-dimensional cavities in coordination cages.
Demonstrated that subtle variations in structure impact binding and recognition.

Implication

Research demonstrates high-resolution characterization of heterometallic coordination cages, indicating structural insights crucial for biological systems.

Abstract

The three-dimensional, non-symmetrical cavities of many biological systems such as enzymes and transport proteins have been shown to routinely distinguish between substrates with minute structural differences, even down to a...

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Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/69df2bece4eeef8a2a6b0e50 https://doi.org/10.1039/d6cc01216g

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From Statistical Mixtures to Structural Insights: Characterisation of Heterometallic [M ₄ L ₆ ] ⁸⁺ Coordination Cages using High Resolution Ion Mobility Mass Spectrometry

Key Points

Implication

Abstract

Discussion

Cite This Study

From Statistical Mixtures to Structural Insights: Characterisation of Heterometallic [M ₄ L ₆ ] ⁸⁺ Coordination Cages using High Resolution Ion Mobility Mass Spectrometry

Key Points

Implication

Abstract

Discussion

Cite This Study

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