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April 15, 2026Diabetes Obesity and Metabolism2 citations

Association of Semaglutide Treatment With Liver Cirrhosis and Hepatocellular Carcinoma in Type 2 Diabetes: A Population‐Based Cohort Study

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AIAssaf IssacharTRTalish RaziIBIlya Borochov

Key Points

  • To investigate the association between semaglutide treatment and the risk of liver cirrhosis and hepatocellular carcinoma in individuals with type 2 diabetes.
  • Population-based cohort study design
  • Included adults with type 2 diabetes
  • Evaluated incidence of liver cirrhosis and hepatocellular carcinoma during treatment
  • Semaglutide treatment did not reduce the risk of liver cirrhosis
  • Semaglutide treatment was not linked to a lower incidence of hepatocellular carcinoma

Abstract

In this real-world study, semaglutide treatment was not associated with a reduced risk of liver cirrhosis or hepatocellular carcinoma among adults with type 2 diabetes mellitus.

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Cite This Study

Issachar et al. (2026) studied this question.

synapsesocial.com/papers/69df2c01e4eeef8a2a6b0ecchttps://doi.org/10.1111/dom.70763
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