Frequency-dependent effects of transauricular vagus nerve stimulation alleviate visceral hypersensitivity, suggesting a novel therapeutic pathway.
This study demonstrated that taVNS alleviates VH, potentially via the nesfatin-1/CRF/CRF1R signaling pathway in the rat hypothalamus. Furthermore, the analgesic effect was frequency-dependent, with 2 Hz taVNS providing a more effective reduction in visceral pain.
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Xu et al. (2026) studied this question.
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