Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 15, 2026Angewandte Chemie

Stereodefined Improbable 3Rotaxane by Post‐Interlocking Ring Editing

View Full Paper
Ask AI
Bookmark
Share

Authors

CWCongsen WangDFDongsheng FuKWKai Wang

Discussion

Loading...

Member takes

Overview

This approach demonstrates an innovative strategy to create stable, enantiopure rotaxanes, suggesting new molecular design methods.

Key Points

  • To develop a method for synthesizing improbable rotaxanes using a stereodefined approach.
  • Utilized a post-interlocking ring editing strategy with covalent organic pillar COP-1 as the ring component.
  • Assembled COP-1 through dynamic covalent imine condensation of chiral macrocycles.
  • Implemented a threading-followed-by-stoppering protocol to produce enantiopure [2]rotaxanes.
  • Conducted imine hydrolysis to convert [2]rotaxanes into improbable [3]rotaxanes.
  • Successfully synthesized improbable [3]rotaxanes while maintaining stereochemical configuration.
  • Achieved enantiopure products through precise control of chiral components.
  • Demonstrated the effectiveness of the post-interlocking ring editing in overcoming statistical limitations.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69df2c88e4eeef8a2a6b1aa3https://doi.org/10.1002/ange.4543318
View Full Paper
Ask AI
Bookmark
Share