Experiments demonstrate that endothelial PAF receptors influence mortality in systemic anaphylaxis, highlighting their role as key mediators.
Platelet-activating factor (PAF) is a key mediator of systemic anaphylaxis. The principal target cell type of PAF in systemic anaphylaxis remains unclear. Endothelial cell-specific PAFR-deficient mice were protected from mortality in PAF-induced systemic anaphylaxis. Endothelial PAFR is suggested to be the principal target mediating PAF-driven mortality in systemic anaphylaxis.
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Suzuki et al. (2026) studied this question.
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