Research demonstrates a novel peptide ligand mimicking the active site of multicopper oxidases, suggesting potential applications in biochemistry.
The active site of multicopper oxidases contains three Cu ions coordinated to a β-sandwich motif. Here, we designed a small peptide ligand that closely mimics the β-sandwich. We verified the sandwich architecture by X-ray crystallography, showing its high resemblance to the active site and ability to coordinate two Cu(II) ions.
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Dang et al. (2026) studied this question.
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