A bis-macrocylic peptide ligand mimicking the β-sandwich active site of multicopper oxidases

Key Points

• This research aims to design a peptide ligand that mimics the active site of multicopper oxidases.
• Designed a bis-macrocyclic peptide ligand
• Verified its structure using X-ray crystallography
• Assessed the ligand's ability to coordinate Cu(II) ions
• The peptide closely resembles the β-sandwich motif found in multicopper oxidases
• Successfully coordinates two Cu(II) ions
• Demonstrates potential for novel biochemical applications