Amplification of the ROCK signaling pathway contributes to hypertension and vascular dysfunction in eNOS null mice.
Hypothesis-generating for ROCK inhibition in nitric oxide-deficient hypertension models; requires human validation before clinical consideration.
These results show that the ROCK signaling pathway is amplified in the eNOS KO mouse kidney and that the enhanced renal vascular tone and selective increase in reactivity to GPCR agonists supports a role for ROCK in the hypertension and vascular dysfunction in the eNOS KO mice.
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Williams et al. (2006) studied this question.
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