Requisite Role of the Cholinergic α7 Nicotinic Acetylcholine Receptor Pathway in Suppressing Gram-Negative Sepsis-Induced Acute Lung Inflammatory Injury
Why the study?
Does activation of the alpha7 nAChR pathway reduce lung injury and mortality in mice with sepsis-induced ALI?
Population
Mice with endotoxin- and live Escherichia coli-induced acute lung injury, including alpha7 nAChR and alpha7…
Comparison
Administration of alpha7 nAChR agonists or vagal… vs Control mice (alpha7 nAChR mice or no…
Design
Preclinical
Authors
Discussion
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Implication
Alpha7 nAChR activation may mitigate sepsis-induced ALI in preclinical models; leaves open translation and requires human trials before any clinical consideration.
Structured PICO
Does activation of the alpha7 nAChR pathway reduce lung injury and mortality in mice with sepsis-induced ALI?
P
Population
Mice with endotoxin- and live Escherichia coli-induced acute lung injury (ALI), including alpha7 nAChR(-/-) and alpha7 nAChR(+/+) mice
I
Intervention
Administration of alpha7 nAChR agonists or vagal denervation
C
Comparator
Control mice (alpha7 nAChR(+/+) mice or no intervention)
O
Outcome
Lung injury severity, mortality, bronchoalveolar lavage MIP-2 production, and transalveolar neutrophil migrationsurrogate
Activation of the alpha7 nAChR pathway reduces chemokine production, neutrophil migration, and mortality in a mouse model of sepsis-induced acute lung injury.
Cite This Study
Su et al. (2009) studied this question.