Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants

Yukihide Momozawa; Rumi Sasai; Yoshiaki Usui; Kouya Shiraishi; Yusuke Iwasaki; Yukari Taniyama; Michael T. Parsons; Keijiro Mizukami; Yuya Sekine; Makoto Hirata; Yoichiro Kamatani; Mikiko Endo; Chihiro Inai; Sadaaki Takata; Hidemi Ito; Takashi Kohno; Koichi Matsuda; Seigo Nakamura; Kokichi Sugano; Teruhiko Yoshida; Hidewaki Nakagawa; Keitaro Matsuo; Yoshinori Murakami; Amanda B. Spurdle; Michiaki Kubo

doi:10.1001/jamaoncol.2022.0476

Abstract

The results of this large-scale registry-based case-control study suggest that pathogenic variants in BRCA1 and BRCA2 were associated with the risk of 7 cancer types. These results indicate broader clinical relevance of BRCA1 and BRCA2 genetic testing.

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Momozawa et al. (2022) studied this question.

synapsesocial.com/papers/69df3e7f6324afb55d5919e1 https://doi.org/10.1001/jamaoncol.2022.0476

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Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants

Abstract

Discussion

Cite This Study

Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants

Abstract

Discussion

Cite This Study

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