Does a high dose of dexmedetomidine reduce the minimum alveolar concentration of isoflurane in patients having surgery?
Patients having surgery
High dose of dexmedetomidine
Control group without dexmedetomidine (anesthesia induction with thiopental and alfentanil)
Minimum Alveolar Concentration (MAC) of isofluranesurrogate
High-dose dexmedetomidine significantly reduces the minimum alveolar concentration of isoflurane required during surgery.
The MAC of isoflurane in the control group was lower than that reported previously in similar patients having surgery, probably due to anesthesia induction with thiopental and alfentanil. Nevertheless, with the high dose of dexmedetomidine, the MAC of isoflurane was still 47% less than that without dexmedetomidine.
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Riku Aantaa
Turku University Hospital
Marja-Leena Jaakola
Turku University Hospital
Antero Kallio
Turku Centre for Biotechnology
Anesthesiology
Turku University Hospital
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Aantaa et al. (Thu,) studied this question.
synapsesocial.com/papers/69df3e8435659245ec6144ac — DOI: https://doi.org/10.1097/00000542-199705000-00008