Why the study?
How does the cardiac messenger RNA expression profile in patients with sepsis differ from that in patients with heart failure?
How does the cardiac messenger RNA expression profile in patients with sepsis differ from that in patients with heart failure?
Sepsis induces a widespread down-regulation of cardiac mitochondrial and sarcomeric genes, which may represent a short-term adaptive response to acute changes in cardiovascular homeostasis.
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Warrants no change in sepsis management; leaves open whether downregulated cardiac genes are adaptive or therapeutic targets.
The expression profile of messenger RNAs in the heart of septic patients reveals striking decreases in expression levels of messenger RNAs that encode proteins involved in cardiac energy production and cardiac contractility and is distinct from that observed in patients with heart failure. Although speculative, the global nature of the decreases in messenger RNA expression for genes involved in cardiac energy production and contractility suggests that these changes may represent a short-term adaptive response of the heart in response to acute change in cardiovascular homeostasis.
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Matkovich et al. (2017) studied this question.
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