Does chlorthalidone or hydrochlorothiazide improve antihypertensive effect compared to placebo?
Chlorthalidone and hydrochlorothiazide demonstrate similar antihypertensive efficacy and electrolyte changes in a double-blind comparison.
Chlorthalidone, hydrochlorthiazide, and a placebo were compared in a double‐blind study. Both drugs used in this study were effective antihypertensive agents and produced similar electrolyte changes.
Bowlus et al. (Sun,) studied this question.