Why the study?
Does conditional knockout of angiopoietin-1 affect vascular development and response to injury in mice?
Does conditional knockout of angiopoietin-1 affect vascular development and response to injury in mice?
Angiopoietin-1 is essential for early vascular development and modulating the vascular response to injury, but is dispensable for maintaining quiescent adult vessels.
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Findings from mice do not support Ang-1 targeting in patients; leaves open its role in human injury responses.
Jeansson et al. (2011) studied this question.
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