Why the study?
How do existing prediction models for mortality risk perform in an independent external validation cohort of chronic dialysis patients?
How do existing prediction models for mortality risk perform in an independent external validation cohort of chronic dialysis patients?
External validation of mortality prediction models in chronic dialysis patients demonstrates reduced performance compared to original derivation cohorts, emphasizing the necessity of external validation before clinical implementation.
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External validation shows reduced accuracy of mortality models in dialysis patients; confirms need for independent testing before clinical use.
Overall, the performance of the models was poorer in the external validation than in the original population, affirming the importance of external validation. Floege et al's models showed the highest predictive performance. The present study is a step forward in the use of a prediction model as a useful tool for nephrologists, using evidence-based medicine that combines individual clinical expertise, patients' choices, and the best available external evidence.
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Ramspek et al. (2017) studied this question.
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