Hypercalcaemia in SCFN appears to be due to abundant levels of 1alpha-hydroxylase in immune infiltrates associated with tissue lesions. This is consistent with previous observations of extrarenal 1alpha-hydroxylase in skin from other granulomatous conditions such as sarcoidosis and slack skin disease.
No takes yet. Share an insight, caveat, or question.
Farooque et al. (2008) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: