Why the study?
Does direct cardiac reprogramming improve cardiac function and reverse fibrosis in chronic myocardial infarction?
Does direct cardiac reprogramming improve cardiac function and reverse fibrosis in chronic myocardial infarction?
Direct cardiac reprogramming shows potential as a novel therapeutic approach for myocardial regeneration and fibrosis reduction in chronic MI and heart failure.
Hypothesis-generating for cardiac reprogramming in chronic MI; does not support clinical translation yet.
These results demonstrate that cardiac reprogramming could repair chronic MI by means of myocardial regeneration and reduction of fibrosis. These findings present opportunities for the development of new therapies for chronic MI and heart failure.
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Tani et al. (2022) studied this question.
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