Reveals that MS4A and CD33 loci increase late-onset Alzheimer's disease risk in a northern Han Chinese population, suggesting APOE ε4-independent genetic mechanisms.
This study provides the first independent evidence that MS4A and CD33 loci are associated with the risk of LOAD in northern Han Chinese population. Genotypes at the two loci confer risk predominantly in APOE ε4-negative subjects.
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Tan et al. (2012) studied this question.
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