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January 25, 2016British Journal of Clinical PharmacologyOpen Access

Scaling factors for thein vitro–in vivoextrapolation (IV–IVE) of renal drug and xenobiotic glucuronidation clearance

Kathleen Knights Shane M. Spencer John K. Fallon Nuy Chau Philip C. Smith John O. Miners

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Abstract

Scaled renal PRO glucuronidation CLint,u,UGT was double that of liver. Renal CLint,u,UGT should be accounted for in the IV-IVE of UGT1A9 and considered for UGT1A6 and 2B7 substrates.

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Knights et al. (2016) studied this question.

synapsesocial.com/papers/69df6df5d5404a0bea593148 https://doi.org/10.1111/bcp.12889

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