Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis

Xinwen Yan; Xinlong Lin; Jian Wu; Lijun Zheng; Yangyang Liu; Fang Wu; Ying Lin; Yishi Lu; Chongyang Huang; Binhai Shen; Hongbin Liu; Ruo Huang; Fengyi Hou; Qian Zhou; Mengyao Song; Ke Liu; Fangqing Zhu; Sheng Li; Yuqing Lin; W. Wang; Ping Li; Wangjun Liao; Fachao Zhi

doi:10.1186/s12916-025-04233-5

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Abstract

Pathological process of CID can be partially explained by compositional alterations in the gut microbiota. Supplementation with hk-B. f reduces 5-FU-stimulated epithelial injury through mitochondrial apoptotic pathway in CID murine models. These preclinical findings suggest hk-B. f merits further investigation as a potential strategy for improving CID, pending clinical validation.

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Yan et al. (2025) studied this question.

synapsesocial.com/papers/69df7b0b1113c054a47a1610 https://doi.org/10.1186/s12916-025-04233-5

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Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis

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Abstract

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Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis

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Abstract

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