April 1, 1998Journal of the American Society of Nephrology

CD59 protects glomerular endothelial cells from immune-mediated thrombotic microangiopathy in rats.

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Population

Rats with a model of immune thrombotic microangiopathy induced by renal artery perfusion of anti-glomerular…

Comparison

Selective renal artery perfusion with F2… vs Perfusion with control mouse IgG followed by…

Design

Preclinical

Authors

MNMasaomi NangakuKanazawa University CACharles E. Alpers JPJeffrey W. PippinUniversity of Washington

Discussion

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Implication

CD59 may protect glomerular endothelium in experimental TMA; leaves open whether modulation alters human disease course.

Structured PICO

Population

Rats with a model of immune thrombotic microangiopathy (TMA) induced by renal artery perfusion of anti-glomerular endothelial cell (anti-GEN) antibody

Intervention

Selective renal artery perfusion with F(ab')2 fragments of anti-CD59 monoclonal antibody to block CD59 activity followed by anti-GEN antibody

Comparator

Perfusion with control mouse IgG followed by anti-GEN antibody or control goat IgG

Outcome

C5b-9 formation in glomeruli, platelet and fibrin deposition, endothelial injury, and renal functionsurrogate

CD59 plays a protective role for glomerular endothelial cells in a rat model of immune-mediated thrombotic microangiopathy by inhibiting C5b-9 formation.

Cite This Study

Nangaku et al. (1998) studied this question.

synapsesocial.com/papers/69dfa3e24fb243fc8e59216f https://doi.org/10.1681/asn.v94590

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CD59 protects glomerular endothelial cells from immune-mediated thrombotic microangiopathy in rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

CD59 protects glomerular endothelial cells from immune-mediated thrombotic microangiopathy in rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider