Why the study?
Does low-molecular-weight heparin prevent life-threatening thromboses in pregnant women with mechanical heart valves compared to unfractionated heparin?
Does low-molecular-weight heparin prevent life-threatening thromboses in pregnant women with mechanical heart valves compared to unfractionated heparin?
Despite the high risk of thrombosis, low-molecular-weight heparin has not been shown to be inferior to unfractionated heparin in pregnant women with mechanical heart valves.
Does not support preferring LMWH over UFH in pregnant women with mechanical valves; leaves open need for randomized trials.
While pregnant women with mechanical heart valves who receive low-molecular-weight heparin for thromboprophylaxis are at extremely high risk of life-threatening thromboses, there is no evidence that low-molecular-weight heparin is inferior to unfractionated heparin.
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James et al. (2006) studied this question.
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