Key result
Anti-TNF-alpha therapy linked to normalized aortic stiffness in rheumatoid arthritis patients vs healthy controls.
Why the study?
Rheumatoid arthritis is associated with increased aortic stiffness that correlates with current inflammation and may be reversible.
Does anti-TNF-alpha therapy reduce aortic pulse-wave velocity in patients with rheumatoid arthritis?
Observational
Does anti-TNF-alpha therapy reduce aortic pulse-wave velocity in patients with rheumatoid arthritis?
Answers are grounded in this paper and cite their sources.
Anti-TNF-alpha therapy reduces aortic stiffness in patients with rheumatoid arthritis, suggesting that controlling inflammation may lower cardiovascular risk.
RA is associated with increased aortic stiffness, which correlates with current but not historical measures of inflammation, suggesting that increased aortic stiffness may be reversible. Indeed, anti-TNF-alpha therapy reduced aortic stiffness to a level comparable to that of healthy individuals. Therefore, effective control of inflammation may be of benefit in reducing cardiovascular risk in patients with RA.
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Mäki-Petäjä et al. (2006) conducted an observational in Rheumatoid Arthritis. Anti-Tumor Necrosis Factor-alpha therapy vs. Healthy individuals was evaluated on Aortic stiffness (aortic pulse-wave velocity). Anti-tumor necrosis factor-alpha therapy reduced aortic stiffness in patients with rheumatoid arthritis to a level comparable to that of healthy individuals.
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