Are eosinophil counts and CRP reliable diagnostic indicators for clozapine-induced myocarditis?
Elevated CRP, rather than eosinophil counts, may serve as an early indicator of clozapine-induced myocarditis, highlighting the need for active monitoring during the first 4 weeks of therapy.
Eosinophil counts should not be relied on for diagnosis of clozapine-related myocarditis, but elevated CRP may be an early indicator of developing myocarditis. Patients starting clozapine should be actively monitored for myocarditis during the first 4 weeks, with extra care taken during week 3.
Ronaldson et al. (Tue,) studied this question.