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January 25, 2021SHILAP Revista de lepidopterologíaOpen Access

Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI

Elisabeth C. van der Slikke Bastiaan S. Star Matijs van Meurs Robert H. Henning Jill Moser Hjalmar R. Bouma

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Abstract

Sepsis-AKI induces mitochondrial DNA damage in the human kidney, without upregulation of mitochondrial quality control mechanisms, which likely resulted in a reduction in mitochondrial mass.

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Cite This Study

Slikke et al. (2021) studied this question.

synapsesocial.com/papers/69dff1a8bdd89ea531860388 https://doi.org/10.1186/s13054-020-03424-1

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Severe Sepsis and Septic ShockOriginal Research · 2013 · 3,993 citations
2Recognizing Sepsis as a Global Health Priority — A WHO ResolutionOriginal Research · 2017 · 1,357 citations
3Sepsis: pathophysiology and clinical managementClinical Trial · 2016 · 1,251 citations
4Acute Renal Failure and SepsisOriginal Research · 2004 · 1,260 citations
5Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapyOriginal Research · 2015 · 226 citations

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