What question did this study set out to answer?

To evaluate the pharmacokinetics and organ distribution of curcumin and its primary metabolites following intravenous administration in mice.

April 24, 2018Biomedical Chromatography

The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice

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Authors

JWJunjun WangSouthwest University of Science and Technology XYXuejin YuEzhou Central Hospital LZLing ZhangGuizhou University

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Implication

Pharmacokinetic study reveals rapid clearance and organ-specific distribution of curcumin and its metabolites in mice, highlighting limited systemic and brain tissue penetration.

Key Points

To evaluate the pharmacokinetics and organ distribution of curcumin and its primary metabolites following intravenous administration in mice.
Administered intravenous curcumin at a dose of 20 mg/kg to mice.
Quantified curcumin, dihydrocurcumin, and tetrahydrocurcumin across plasma, liver, kidney, and brain tissues using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Plasma AUC0-∞ reached 107.0 ± 18.3 (mg/L)·min for curcumin, 12.0 ± 4.0 (mg/L)·min for tetrahydrocurcumin, and 6.0 ± 1.2 (mg/L)·min for dihydrocurcumin, with elimination half-lives of 32.4 ± 10.8, 5.6 ± 1.8, and 6.4 ± 2.4 minutes, respectively.
Curcumin exposure in plasma was 6-fold greater than in liver, kidney, and brain; tetrahydrocurcumin localized to liver, dihydrocurcumin to kidney, and only unmetabolized curcumin reached brain tissue.

Cite This Study

Wang et al. (2018) studied this question.

synapsesocial.com/papers/69dff1a8bdd89ea531860398 https://doi.org/10.1002/bmc.4267

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Implication

Pharmacokinetic study reveals rapid clearance and organ-specific distribution of curcumin and its metabolites in mice, highlighting limited systemic and brain tissue penetration.

The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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