Inhibition of monosodium urate monohydrate crystal–induced acute inflammation by retrovirally transfected prostaglandin D synthase

In this murine air-pouch model of MSU crystal-induced inflammation, retrovirally transfected H-PGDS cDNA could reduce cellular infiltration, at least partly by inhibiting MIP-2 and IL-1beta. These findings suggest that gene therapy with H-PGDS may be useful for treating inflammatory diseases.