The data support the notion that HIF-1α plays a role in brain edema formation and BBB disruption via a molecular pathway cascade involving AQP-4 and MMP-9. Pharmacological blockade of this pathway in patients with TBI may provide a novel therapeutic strategy.
No takes yet. Share an insight, caveat, or question.
Higashida et al. (2010) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: