April 1, 1999Diabetes

Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity.

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Why the study?

Does insulin infusion improve arterial stiffness differently in obese compared to nonobese men?

Population

23 men, comprising 8 nonobese, 8 obese, and 7 men in a saline control study.

Comparison

Sequential 2-hour insulin infusions of 1 and 2… vs Saline infusion (control study).

Design

Cohort

Follow-up

4 hours

Authors

JWJukka WesterbackaSanofi (France)SVSatu VehkavaaraHelsinki University Hospital RBRobert BergholmMinerva Foundation

Discussion

Member takes

Implication

Obesity may blunt insulin's acute vascular effects; hypothesis-generating for insulin resistance in arterial stiffness and cardiovascular risk.

Structured PICO

Does insulin infusion improve arterial stiffness differently in obese compared to nonobese men?

Population

23 men, comprising 8 nonobese (aged 25 +/- 1 years, BMI 22.7 +/- 0.4 kg/m2), 8 obese (aged 27 +/- 2 years, BMI 30.6 +/- 0.9 kg/m2), and 7 men in a saline control study.

Intervention

Sequential 2-hour insulin infusions of 1 and 2 mU/kg/min under normoglycemic-hyperinsulinemic conditions.

Comparator

Saline infusion (control study).

Outcome

Change in augmentation index (a measure of arterial stiffness) and forearm blood flow.surrogate

Obesity is characterized by a marked resistance to insulin's normal physiological effect of decreasing central arterial stiffness.

Cite This Study

Westerbacka et al. (1999) studied this question.

synapsesocial.com/papers/69dffb6993e101b251e9c562 https://doi.org/10.2337/diabetes.48.4.821

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Implication

Obesity may blunt insulin's acute vascular effects; hypothesis-generating for insulin resistance in arterial stiffness and cardiovascular risk.